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Journal of Biomedical Optics

Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues
Author(s): Kelsey M. Kennedy; Robert A. McLaughlin; Brendan F. Kennedy; Alan Tien; Bruce Latham; Christobel M. Saunders; David D. Sampson
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Paper Abstract

Optical coherence elastography (OCE) is an emerging imaging technique that probes microscale mechanical contrast in tissues with the potential to differentiate healthy and malignant tissues. However, conventional OCE techniques are limited to imaging the first 1 to 2 mm of tissue in depth. We demonstrate, for the first time, OCE measurements deep within human tissues using needle OCE, extending the potential of OCE as a surgical guidance tool. We use needle OCE to detect tissue interfaces based on mechanical contrast in both normal and malignant breast tissues in freshly excised human mastectomy samples, as validated against histopathology. Further, we demonstrate the feasibility of in situ measurements <4  cm from the tissue surface using ultrasound guidance of the OCE needle probe. With further refinement, our method may potentially aid in accurate detection of the boundary of the tumor to help ensure full removal of all malignant tissues, which is critical to the success of breast-conserving surgery.

Paper Details

Date Published: 23 December 2013
PDF: 9 pages
J. Biomed. Opt. 18(12) 121510 doi: 10.1117/1.JBO.18.12.121510
Published in: Journal of Biomedical Optics Volume 18, Issue 12
Show Author Affiliations
Kelsey M. Kennedy, The Univ. of Western Australia (Australia)
Robert A. McLaughlin, The Univ. of Western Australia (Australia)
Brendan F. Kennedy, The Univ. of Western Australia (Australia)
Alan Tien, The Univ. of Western Australia (Australia)
Bruce Latham, PathWest (Australia)
Christobel M. Saunders, The Univ. of Western Australia (Australia)
David D. Sampson, The Univ. of Western Australia (Australia)

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