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Journal of Biomedical Optics

Shear modulus imaging by direct visualization of propagating shear waves with phase-sensitive optical coherence tomography
Author(s): Shaozhen Song; Zhihong Huang; Thu-Mai Nguyen; Emily Y. Wong; Bastien Arnal; Matthew O'Donnell; Ruikang K. Wang
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Paper Abstract

We propose an integrated method combining low-frequency mechanics with optical imaging to map the shear modulus within the biological tissue. Induced shear wave propagating in tissue is tracked in space and time using phase-sensitive optical coherence tomography (PhS-OCT). Local estimates of the shear-wave speed obtained from tracking results can image the local shear modulus. A PhS-OCT system remotely records depth-resolved, dynamic mechanical waves at an equivalent frame rate of ∼47  kHz with the high spatial resolution. The proposed method was validated by examining tissue-mimicking phantoms made of agar and light scattering material. Results demonstrate that the shear wave imaging can accurately map the elastic moduli of these phantoms.

Paper Details

Date Published: 8 November 2013
PDF: 8 pages
J. Biomed. Opt. 18(12) 121509 doi: 10.1117/1.JBO.18.12.121509
Published in: Journal of Biomedical Optics Volume 18, Issue 12
Show Author Affiliations
Shaozhen Song, Univ. of Washington (United States)
Zhihong Huang, Univ. of Dundee (United Kingdom)
Thu-Mai Nguyen, Univ. of Washington (United States)
Emily Y. Wong, Univ. of Washington (United States)
Bastien Arnal, Univ. of Washington (United States)
Matthew O'Donnell, Univ. of Washington (United States)
Ruikang K. Wang, Univ. of Washington (United States)


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