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Journal of Biomedical Optics

Dynamic optical coherence tomography measurements of elastic wave propagation in tissue-mimicking phantoms and mouse cornea in vivo
Author(s): Jiasong Li; Shang Wang; Ravi Kiran Manapuram; Manmohan Singh; Floredes M. Menodiado; Salavat Aglyamov; Stanislav Y. Emelianov; Michael D. Twa; Kirill V. Larin
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Paper Abstract

We demonstrate the use of phase-stabilized swept-source optical coherence tomography to assess the propagation of low-amplitude (micron-level) waves induced by a focused air-pulse system in tissue-mimicking phantoms, a contact lens, a silicone eye model, and the mouse cornea in vivo. The results show that the wave velocity can be quantified from the analysis of wave propagation, thereby enabling the estimation of the sample elasticity using the model of surface wave propagation for the tissue-mimicking phantoms. This noninvasive, noncontact measurement technique involves low-force methods of tissue excitation that can be potentially used to assess the biomechanical properties of ocular and other delicate tissues in vivo.

Paper Details

Date Published: 2 October 2013
PDF: 7 pages
J. Biomed. Opt. 18(12) 121503 doi: 10.1117/1.JBO.18.12.121503
Published in: Journal of Biomedical Optics Volume 18, Issue 12
Show Author Affiliations
Jiasong Li, Univ. of Houston (United States)
Shang Wang, Univ. of Houston (United States)
Ravi Kiran Manapuram, Univ. of Houston (United States)
Manmohan Singh, Univ. of Houston (United States)
Floredes M. Menodiado, Univ. of Houston (United States)
Salavat Aglyamov, The Univ. of Texas at Austin (United States)
Stanislav Y. Emelianov, The Univ. of Texas at Austin (United States)
Michael D. Twa, Univ. of Houston (United States)
Kirill V. Larin, Univ. of Houston (United States)

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