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Journal of Biomedical Optics

Parameters affecting ultrafast laser microsurgery of subepithelial voids for scar treatment in vocal folds
Author(s): Murat Yildirim; Onur Ferhanoglu; James B. Kobler; Steven M. Zeitels; Adela Ben-Yakar
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Paper Abstract

Toward developing a new method for restoring tissue viscoelasticity in scarred vocal folds, we previously proposed a method to localize biomaterials within subepithelial voids ablated using ultrafast laser pulses. The clinical implementation of this method necessitates the quantification of the laser parameters for ablating scarred tissue. Here, we present a comprehensive study of these parameters including ablation threshold and bubble lifetime in healthy and scarred tissues. We also present a new method for extracting tissue-specific ablation threshold and scattering lengths of different tissue layers. This method involves finding the ablation threshold at multiple depths and solving the equations based on Beer’s law of light attenuation for each depth to estimate the unknown parameters. Measured threshold fluences were 1.75  J/cm 2 for vocal folds and 0.5  J/cm 2 for cheek pouches for 3-ps, 776-nm laser pulses. Scarred pouches exhibited 30% lower threshold than healthy pouches, possibly due to the degraded mechanical properties of scarred collagen during wound healing. The analysis of tissue architecture indicated a direct correlation between the ablation threshold and tissue tensile strength and that the bubble lifetime is inversely related to tissue stiffness. Overall, this study sheds light on the required laser parameters for successful implementation of ultrafast laser ablation for phonosurgery.

Paper Details

Date Published: 5 November 2013
PDF: 15 pages
J. Biomed. Opt. 18(11) 118001 doi: 10.1117/1.JBO.18.11.118001
Published in: Journal of Biomedical Optics Volume 18, Issue 11
Show Author Affiliations
Murat Yildirim, The Univ. of Texas at Austin (United States)
Onur Ferhanoglu, The Univ. of Texas at Austin (United States)
James B. Kobler, Massachusetts General Hospital (United States)
Steven M. Zeitels, Massachusetts General Hospital (United States)
Adela Ben-Yakar, The Univ. of Texas at Austin (United States)

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