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Journal of Biomedical Optics

Ultrasound-heated photoacoustic flowmetry
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Paper Abstract

We report the development of photoacoustic flowmetry assisted by high-intensity focused ultrasound (HIFU). This novel method employs HIFU to generate a heating impulse in the flow medium, followed by photoacoustic monitoring of the thermal decay process. Photoacoustic flowmetry in a continuous medium remains a challenge in the optical diffusive regime. Here, both the HIFU heating and photoacoustic detection can focus at depths beyond the optical diffusion limit (∼1  mm in soft tissue). This method can be applied to a continuous medium, i.e., a medium without discrete scatterers or absorbers resolvable by photoacoustic imaging. Flow speeds up to 41  mm⋅s −1 have been experimentally measured in a blood phantom covered by 1.5-mm-thick tissue.

Paper Details

Date Published: 5 November 2013
PDF: 6 pages
J. Biomed. Opt. 18(11) 117003 doi: 10.1117/1.JBO.18.11.117003
Published in: Journal of Biomedical Optics Volume 18, Issue 11
Show Author Affiliations
Lidai Wang, Washington Univ. School of Medicine in St. Louis (United States)
Junjie Yao, Washington Univ. in St. Louis (United States)
Konstantin I. Maslov, Washington Univ. in St. Louis (United States)
Wenxin Xing, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)

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