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Journal of Biomedical Optics • Open Access

In vitro and in vivo three-dimensional velocity vector measurement by three-beam spectral-domain Doppler optical coherence tomography

Paper Abstract

We developed a three-beam Doppler optical coherence tomography (OCT) system that enables measurement of the velocity vector of moving particles in three-dimensions (3-D). The spatial orientation as well as the magnitude of motion can be determined without prior knowledge of the geometry of motion. The system combines three spectral-domain OCT interferometers whose sample beams are focused at the sample by a common focusing lens at three different angles. This provides three spatially independent velocity components simultaneously from which the velocity vector can be reconstructed. We demonstrate the system in a simple test object (rotating disc), a flow phantom, and for blood flow measurements in the retina of a healthy human subject. Measurements of blood flow at a venous bifurcation achieve a good agreement between in- and outflow and demonstrate the reliability of the method.

Paper Details

Date Published: 18 November 2013
PDF: 12 pages
J. Biomed. Opt. 18(11) 116010 doi: 10.1117/1.JBO.18.11.116010
Published in: Journal of Biomedical Optics Volume 18, Issue 11
Show Author Affiliations
Wolfgang Trasischker, Medizinische Univ. Wien (Austria)
René M. Werkmeister, Medizinische Univ. Wien (Austria)
Stefan Zotter, Medizinische Univ. Wien (Austria)
Bernhard Baumann, Medizinische Univ. Wien (Austria)
Teresa Torzicky, Medizinische Univ. Wien (Austria)
Michael Pircher, Medizinische Univ. Wien (Austria)
Christoph K. Hitzenberger, Medizinische Univ. Wien (Austria)

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