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Journal of Biomedical Optics • Open Access

Multichannel scan surface plasmon resonance biochip with stationary optics and baseline updating capability
Author(s): Cheng Wang; Ruping Liu; Wei Zhang; Yujian Wang; Kai Xu; Zhao Yue; Guohua Liu

Paper Abstract

An on-chip spectral surface plasmon resonance (SPR) biosensor with three parallel channels has been built for biomolecule detections. It is capable of updating intensity baselines to suppress errors induced by light source instability. In order to minimize structure and reduce positional regression uncertainty, the scan operations are achieved by timely changing optical media instead of conventional mechanical scan. The detection results of human immunoglobulin G (hIgG) demonstrated that the baseline updating improves the limitation of detection of hIgG concentration from ∼86.1 to ∼17.4  ng/mL.

Paper Details

Date Published: 5 November 2013
PDF: 5 pages
J. Biomed. Opt. 18(11) 115002 doi: 10.1117/1.JBO.18.11.115002
Published in: Journal of Biomedical Optics Volume 18, Issue 11
Show Author Affiliations
Cheng Wang, Columbia Univ. (United States)
Ruping Liu, Nankai Univ. (China)
Wei Zhang, Nankai Univ. (China)
Yujian Wang, Nankai Univ. (China)
Kai Xu, Nankai Univ. (China)
Zhao Yue, Nankai Univ. (China)
Guohua Liu, Nankai Univ. (China)

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