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Journal of Biomedical Optics

Trimodal detection of early childhood caries using laser light scanning and fluorescence spectroscopy: clinical prototype
Author(s): Liang Zhang; Amy S. Kim; Jeremy S. Ridge; Leonard Y. Nelson; Joel H. Berg; Eric J. Seibel
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Paper Abstract

There is currently a need for a safe and effective way to detect and diagnose early stages of childhood caries. A multimodal optical clinical prototype for diagnosing caries demineralization in vivo has been developed. The device can be used to quickly image and screen for any signs of demineralized enamel by obtaining high-resolution and high-contrast surface images using a 405-nm laser as the illumination source, as well as obtaining autofluorescence and bacterial fluorescence images. When a suspicious region of demineralization is located, the device also performs dual laser fluorescence spectroscopy using 405- and 532-nm laser excitation. An autofluorescence ratio of the two excitation lasers is computed and used to quantitatively diagnose enamel health. The device was tested on five patients in vivo as well as on 28 extracted teeth with clinically diagnosed carious lesions. The device was able to provide detailed images that highlighted the lesions identified by the clinicians. The autofluorescence spectroscopic ratios obtained from the extracted teeth successfully quantitatively discriminated between sound and demineralized enamel.

Paper Details

Date Published: 28 August 2013
PDF: 9 pages
J. Biomed. Opt. 18(11) 111412 doi: 10.1117/1.JBO.18.11.111412
Published in: Journal of Biomedical Optics Volume 18, Issue 11
Show Author Affiliations
Liang Zhang, Univ. of Washington (United States)
Amy S. Kim, Univ. of Washington (United States)
Jeremy S. Ridge, Univ. of Washington (United States)
Leonard Y. Nelson, Univ. of Washington (United States)
Joel H. Berg, Univ. of Washington (United States)
Eric J. Seibel, Univ. of Washington (United States)

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