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Journal of Biomedical Optics

Thermographic investigation of tumor size, and its correlation to tumor relative temperature, in mice with transplantable solid breast carcinoma
Author(s): Michal Tepper; Asaf Shoval; Oshrit Hoffer; Hila Confino; Michael Schmidt; Itzhak Kelson; Yona Keisari; Israel Gannot
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Paper Abstract

Treating cancer is one of the major challenges of modern medicine. Since mice models are an important tool in cancer treatment research, it is required to assess murine tumor development. Existing methods for investigating tumor development are either high cost and limited by their availability or suffer from low accuracy and reproducibility. In order to overcome these drawbacks, thermography may be used. DA3 breast cancer carcinoma tumors in 12  Balb/c mice were thermally imaged and monitored for a period of several weeks. Eight mice were treated with diffusing alpha emitters radiation therapy (DaRT) wires, while four were treated with inert wires. For large tumors, the area was estimated by analyzing thermal images and was found to be in correlation with manual caliper measurements. In addition, the correlation between tumor area and relative temperatures was calculated and compared to previous works. Temperature differences were larger for tumors treated with DaRT wires than tumors with inert wires. These correlations can be used to assist in tumor size estimation and reveal information regarding its metabolic state. Overall, thermography was shown to be a promising tool for assessing tumor development with the additional advantages of being nonradiative and potentially providing indication of intratumoral biological processes.

Paper Details

Date Published: 12 August 2013
PDF: 11 pages
J. Biomed. Opt. 18(11) 111410 doi: 10.1117/1.JBO.18.11.111410
Published in: Journal of Biomedical Optics Volume 18, Issue 11
Show Author Affiliations
Michal Tepper, Tel Aviv Univ. (Israel)
Asaf Shoval, Tel Aviv Univ. (Israel)
Oshrit Hoffer, Tel Aviv Univ. (Israel)
Hila Confino, Tel Aviv Univ. (Israel)
Michael Schmidt, Tel Aviv Univ. (Israel)
Itzhak Kelson, Tel Aviv Univ. (Israel)
Yona Keisari, Tel Aviv Univ. (Israel)
Israel Gannot, Tel Aviv Univ. (Israel)

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