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Journal of Biomedical Optics

Fast depth-sensitive fluorescence measurements in turbid media using cone shell configuration
Author(s): Yi Hong Ong; Quan Liu
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Paper Abstract

Depth-sensitive fluorescence spectroscopy in a two-layered epithelial tissue phantom was demonstrated using a cone shell configuration implemented by an axicon lens and a fiber assembly including five rings of collection fibers. Each collection fiber ring was located at a different radial distance away from the center, for which fluorescence measurements from all rings showed a larger range of sensitivities to the top and bottom layers compared to the previously reported cone shell configuration. Furthermore, multiple fluorescence spectra corresponding to a range of successive targeted depths can be obtained simultaneously, which shortened data acquisition dramatically and eliminated the mechanical moving components required for depth-sensitive optical measurements in the previous setup. This new setup therefore would be preferred in a clinical setting.

Paper Details

Date Published: 18 November 2013
PDF: 4 pages
J. Biomed. Opt. 18(11) 110503 doi: 10.1117/1.JBO.18.11.110503
Published in: Journal of Biomedical Optics Volume 18, Issue 11
Show Author Affiliations
Yi Hong Ong, Nanyang Technological Univ. (Singapore)
Quan Liu, Nanyang Technological Univ. (Singapore)

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