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Journal of Biomedical Optics

Substantiation of medical and technical requirements for noninvasive spectrophotometric diagnostic devices
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Paper Abstract

A scientific approach to the formulation of medical and technical requirements (MTRs) for noninvasive spectrophotometric diagnostic devices using optical technologies such as laser Doppler flowmetry and absorption spectroscopy is proposed. The theoretical modeling framework, metrological certification, and testing of these devices are still in the early stages of development. The theoretical estimation of the received signal levels for wavelengths between 514 and 940 nm is highly dependent on the blood volume level in the subject tissue. The proposed approach allows, in particular, the calculation of technical and metrological performance constraints of the instruments, such as the ranges of the sensitivity and power-related signal-to-noise ratios for different spectral channels and different biomedical (biochemical and physiological) parameters. Substantiation of specialized MTRs for the noninvasive spectrophotometric diagnostic devices can enable them to develop to the level of standardized measurement techniques.

Paper Details

Date Published: 28 October 2013
PDF: 8 pages
J. Biomed. Opt. 18(10) 107009 doi: 10.1117/1.JBO.18.10.107009
Published in: Journal of Biomedical Optics Volume 18, Issue 10
Show Author Affiliations
Andrey V. Dunaev, Univ. of Dundee (United Kingdom)
Evgeny A. Zherebtsov, Oryol State Technical Univ. (Russian Federation)
Dimitrii A. Rogatkin, MONIKI (Russian Federation)
Neil A. Stewart, Univ. of Dundee (United Kingdom)
Sergei G. Sokolovski, Univ. of Dundee (United Kingdom)
Edik U. Rafailov, Univ. of Dundee (United Kingdom)


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