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Journal of Biomedical Optics

Determination of optical properties by interstitial white light spectroscopy using a custom fiber optic probe
Author(s): Timothy M. Baran; Michael C. Fenn; Thomas H. Foster
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Paper Abstract

We demonstrate interstitial recovery of absorption and scattering coefficients using a custom optical probe and a Monte Carlo (MC)–based recovery algorithm. The probe consists of six side-firing spectroscopy fibers contained in a 1.1-mm outer diameter cladding, with each fiber having a different axial and angular position on the probe. Broadband white light is delivered by one of the fibers and is detected steady-state by the remaining fibers. These spatially and spectrally resolved data are analyzed using a MC-based fitting algorithm in order to extract the local optical properties. The technique was verified in tissue-simulating phantoms consisting of Intralipid-20% as a scatterer and either manganese meso-tetra (4-sulfanatophenyl) porphine or intact human erythrocytes as an absorber. Absorption coefficients were recovered with a mean error of 9% and scattering coefficients were recovered with a mean error of 19%, whereas the hemoglobin oxygen saturation was recovered with a mean error of 12%. These results demonstrate the feasibility of optical property recovery for situations in which surface-contact spectroscopy is not a possibility, and where only a single probe can be inserted into the tissue.

Paper Details

Date Published: 22 October 2013
PDF: 10 pages
J. Biomed. Opt. 18(10) 107007 doi: 10.1117/1.JBO.18.10.107007
Published in: Journal of Biomedical Optics Volume 18, Issue 10
Show Author Affiliations
Timothy M. Baran, Univ. of Rochester Medical Ctr. (United States)
Michael C. Fenn, Univ. of Rochester (United States)
Thomas H. Foster, Univ. of Rochester Medical Ctr. (United States)

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