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Journal of Biomedical Optics • Open Access

Optical parametric oscillator-based photoacoustic detection of hydrogen cyanide for biomedical applications
Author(s): Denis D. Arslanov; Maria P. Castro; Noortje A. Creemers; Anne H. Neerincx; Marius Spunei; Julien Mandon; Simona M. Cristescu; Peter J. Merkus; Frans J. Harren

Paper Abstract

A versatile, continuous wave, optical parametric oscillator is used in combination with photoacoustic spectroscopy for long-term trace gas experiments of volatile compounds emitted by biological samples. The optical parametric oscillator-based spectrometer (wavelength near 3 μm, 8-MHz linewidth, output power ∼1  W ) is successfully tested for the detection of hydrogen cyanide (HCN) emission from clover leaves, and Pseudomonas bacteria; in addition, the presence of HCN in exhaled human breath is measured. For specific experiments, the spectrometer is operated continuously up to 10 days and has a detection limit of 0.4 parts-per-billion volume of HCN in air over 10 s, using the P8 rotational line in the ν 3 vibrational band of HCN at 3287.25  cm −1 . This results in an overall sensitivity of the system of 2.5×10 −9   cm −1  Hz −1/2 .

Paper Details

Date Published: 2 October 2013
PDF: 9 pages
J. Biomed. Opt. 18(10) 107002 doi: 10.1117/1.JBO.18.10.107002
Published in: Journal of Biomedical Optics Volume 18, Issue 10
Show Author Affiliations
Denis D. Arslanov, Radboud Univ. Nijmegen (Netherlands)
Maria P. Castro, Univ. Estaudual do Norte Fluminense (Brazil)
Noortje A. Creemers, Radboud Univ. Nijmegen (Netherlands)
Anne H. Neerincx, Radboud Univ. Nijmegen (Netherlands)
Marius Spunei, Radboud Univ. Nijmegen (Netherlands)
Julien Mandon, Radboud Univ. Nijmegen (Netherlands)
Simona M. Cristescu, Radboud Univ. Nijmegen (Netherlands)
Peter J. Merkus, Radboud Univ. Nijmegen Medical Ctr. (Netherlands)
Frans J. Harren, Radboud Univ. Nijmegen (Netherlands)

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