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Journal of Biomedical Optics • Open Access

Wide velocity range Doppler optical microangiography using optimized step-scanning protocol with phase variance mask
Author(s): Lei Shi; Jia Qin; Roberto Reif; Ruikang K. Wang

Paper Abstract

We propose a simple and optimized method for acquiring a wide velocity range of blood flow using Doppler optical microangiography. After characterizing the behavior of the scanner in the fast scan axis, a step-scanning protocol is developed by utilizing repeated A-scans at each step. Multiple velocity range images are obtained by the high-pass filtering and Doppler processing of complex signals between A-scans within each step with different time intervals. A phase variance mask is then employed to segment meaningful Doppler flow signals from noisy phase background. The technique is demonstrated by imaging in vivo mouse brain with skull left intact to provide bidirectional images of cerebral blood flow with high quality and wide velocity range.

Paper Details

Date Published: 28 October 2013
PDF: 5 pages
J. Biomed. Opt. 18(10) 106015 doi: 10.1117/1.JBO.18.10.106015
Published in: Journal of Biomedical Optics Volume 18, Issue 10
Show Author Affiliations
Lei Shi, Univ. of Washington (United States)
Jia Qin, Univ. of Washington (United States)
Roberto Reif, Univ. of Washington (United States)
Ruikang K. Wang, Univ. of Washington (United States)

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