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Journal of Biomedical Optics • Open Access

Detection of cerebral ischemia using the power spectrum of the pulse wave measured by near-infrared spectroscopy
Author(s): Akira Ebihara; Yuichi Tanaka; Takehiko Konno; Shingo Kawasaki; Michiyuki Fujiwara; Eiju Watanabe

Paper Abstract

The diagnosis and medical treatment of cerebral ischemia are becoming more important due to the increase in the prevalence of cerebrovascular disease. However, conventional methods of evaluating cerebral perfusion have several drawbacks: they are invasive, require physical restraint, and the equipment is not portable, which makes repeated measurements at the bedside difficult. An alternative method is developed using near-infrared spectroscopy (NIRS). NIRS signals are measured at 44 positions (22 on each side) on the fronto-temporal areas in 20 patients with cerebral ischemia. In order to extract the pulse-wave component, the raw total hemoglobin data recorded from each position are band-pass filtered (0.8 to 2.0 Hz) and subjected to a fast Fourier transform to obtain the power spectrum of the pulse wave. The ischemic region is determined by single-photon emission computed tomography. The pulse-wave power in the ischemic region is compared with that in the symmetrical region on the contralateral side. In 17 cases (85%), the pulse-wave power on the ischemic side is significantly lower than that on the contralateral side, which indicates that the transmission of the pulse wave is attenuated in the region with reduced blood flow. Pulse-wave power might be useful as a noninvasive marker of cerebral ischemia.

Paper Details

Date Published: 1 October 2013
PDF: 9 pages
J. Biomed. Opt. 18(10) 106001 doi: 10.1117/1.JBO.18.10.106001
Published in: Journal of Biomedical Optics Volume 18, Issue 10
Show Author Affiliations
Akira Ebihara, Jichi Medical Univ. (Japan)
Yuichi Tanaka, Jichi Medical Univ. (Japan)
Takehiko Konno, Jichi Medical Univ. (Japan)
Shingo Kawasaki, Hitachi Medical Corp. (Japan)
Michiyuki Fujiwara, Hitachi Medical Corp. (Japan)
Eiju Watanabe, Jichi Medical Univ. (Japan)

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