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Journal of Biomedical Optics

LipImage™ 815: novel dye-loaded lipid nanoparticles for long-term and sensitive in vivo near-infrared fluorescence imaging
Author(s): Aurelie Jacquart; Michelle Keramidas; Julian Vollaire; Raphaël Boisgard; Géraldine Pottier; Emilie Rustique; Frédérique Mittler; Fabrice Navarro; Jerome Boutet; Jean-Luc Coll; Isabelle Texier
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Paper Abstract

A new contrast agent, LipImage™ 815, has been designed and compared to previously described indocyanine green (ICG)-loaded lipid nanoparticles (ICG-lipidots®). Both contrast agents display similar size (50-nm diameter), zeta potential, high IC50 in cellular studies, near-infrared absorption and emission wavelengths in the “imaging window,” long-term shelf colloidal and optical stabilities with high brightness (<10 6   L mol −1  cm −1 ) in ready-to-use storage conditions in aqueous buffer (4°C in dark), therefore being promising fluorescence contrast agents for in vivo imaging. However, while ICG-lipidots® display a relatively short plasma lifetime, LipImage™ 815 circulates in blood for longer times, allowing the efficient uptake of fluorescence signal in human prostate cancer cells implanted in mice. Prolonged tumor labeling is observed for more than 21 days.

Paper Details

Date Published: 30 July 2013
PDF: 9 pages
J. Biomed. Opt. 18(10) 101311 doi: 10.1117/1.JBO.18.10.101311
Published in: Journal of Biomedical Optics Volume 18, Issue 10
Show Author Affiliations
Aurelie Jacquart, CEA-LETI-Minatec (France)
Michelle Keramidas, Institut Albert Bonniot (France)
Julian Vollaire, Institut Albert Bonniot (France)
Raphaël Boisgard, INSERM (France)
Géraldine Pottier, INSERM (France)
Emilie Rustique, CEA-LETI-Minatec (France)
Frédérique Mittler, Commissariat à l'Énergie Atomique (France)
Fabrice Navarro
Jerome Boutet, Commissariat à l'Énergie Atomique (France)
Jean-Luc Coll, Institut Albert Bonniot (France)
Isabelle Texier, CEA-LETI-Minatec (France)

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