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Journal of Biomedical Optics • Open Access

Near-infrared fluorescence goggle system with complementary metal–oxide–semiconductor imaging sensor and see-through display
Author(s): Yang Liu; Raphael Njuguna; Thomas Matthews; Walter J. Akers; Gail P. Sudlow; Suman B. Mondal; Rui Tang; Viktor Gruev; Samuel Achilefu

Paper Abstract

We have developed a near-infrared (NIR) fluorescence goggle system based on the complementary metal–oxide–semiconductor active pixel sensor imaging and see-through display technologies. The fluorescence goggle system is a compact wearable intraoperative fluorescence imaging and display system that can guide surgery in real time. The goggle is capable of detecting fluorescence of indocyanine green solution in the picomolar range. Aided by NIR quantum dots, we successfully used the fluorescence goggle to guide sentinel lymph node mapping in a rat model. We further demonstrated the feasibility of using the fluorescence goggle in guiding surgical resection of breast cancer metastases in the liver in conjunction with NIR fluorescent probes. These results illustrate the diverse potential use of the goggle system in surgical procedures.

Paper Details

Date Published: 31 May 2013
PDF: 8 pages
J. Biomed. Opt. 18(10) 101303 doi: 10.1117/1.JBO.18.10.101303
Published in: Journal of Biomedical Optics Volume 18, Issue 10
Show Author Affiliations
Yang Liu, Washington Univ. in St. Louis (United States)
Raphael Njuguna, Washington Univ. in St. Louis (United States)
Thomas Matthews, Washington Univ. in St. Louis (United States)
Walter J. Akers, Washington Univ. in St. Louis (United States)
Gail P. Sudlow, Washington Univ. in St. Louis (United States)
Suman B. Mondal, Washington Univ. in St. Louis (United States)
Rui Tang, Washington Univ. in St. Louis (United States)
Viktor Gruev, Washington Univ. in St. Louis (United States)
Samuel Achilefu, Washington Univ. in St. Louis (United States)


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