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Journal of Biomedical Optics • Open Access

Development of a three-dimensional surface imaging system for melanocytic skin lesion evaluation
Author(s): Androniki D. Tosca; Athanasios Kokolakis; Konstantinos Lasithiotakis; Athanasios Zacharopoulos; Xenophon Zabulis; Ioannis Marnelakis; Jorge Ripoll; Constantine Stephanidis

Paper Abstract

Even though surface morphology is always taken into account when assessing clinically pigmented skin lesions, it is not captured by most modern imaging systems using digital imaging. Our aim is to develop a novel three-dimensional (3D) imaging technique to record detailed information of the surface anatomy of melanocytic lesions that will enable improved classification through digital imaging. The apparatus consists of three high-resolution cameras, a light source, and accompanying software. Volume measurements of specific phantoms using volumetric tubes render slightly lower values than those obtained by our 3D imaging system (mean%±SD, 3.8%±0.98, P<0.05). To examine the reproducibility of the method, sequential imaging of melanocytic lesions is carried out. The mean%±SD differences of area, major axis length, volume, and maximum height are 2.1%±1.1, 0.9%±0.8, 3.8%±2.9, and 2.5%±3.5, respectively. Thirty melanocytic lesions are assessed, including common and dysplastic nevi and melanomas. There is a significant difference between nevi and melanomas in terms of variance in height and boundary asymmetry (P<0.001). Moreover, dysplastic nevi have significantly higher variances in pigment density values than common nevi (P<0.001). Preliminary data suggest that our instrument has great potential in the evaluation of the melanocytic lesions. However, these findings should be confirmed in larger-scale studies.

Paper Details

Date Published: 7 January 2013
PDF: 13 pages
J. Biomed. Opt. 18(1) 016009 doi: 10.1117/1.JBO.18.1.016009
Published in: Journal of Biomedical Optics Volume 18, Issue 1
Show Author Affiliations
Androniki D. Tosca, Univ. of Crete (Greece)
Athanasios Kokolakis, Univ. of Crete (Greece)
Konstantinos Lasithiotakis, Univ. of Crete (Greece)
Athanasios Zacharopoulos, Foundation for Research and Technology-Hellas (Greece)
Xenophon Zabulis, Foundation for Research and Technology-Hellas (Greece)
Ioannis Marnelakis, Univ. of Crete (Greece)
Jorge Ripoll, Foundation for Research and Technology-Hellas (Greece)
Constantine Stephanidis, Foundation for Research and Technology-Hellas (Greece)

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