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Journal of Biomedical Optics

Photoacoustic signal amplification through plasmonic nanoparticle aggregation
Author(s): Carolyn L. Bayer; Seung Yun Nam; Yun-Sheng Chen; Stanislav Y. Emelianov
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Paper Abstract

Photoacoustic imaging, using targeted plasmonic metallic nanoparticles, is a promising noninvasive molecular imaging method. Analysis of the photoacoustic signal generated by plasmonic metallic nanoparticles is complex because of the dependence upon physical properties of both the nanoparticle and the surrounding environment. We studied the effect of the aggregation of gold nanoparticles on the photoacoustic signal amplitude. We found that the photoacoustic signal from aggregated silica-coated gold nanoparticles is greatly enhanced in comparison to disperse silica-coated gold nanoparticles. Because cellular uptake and endocytosis of nanoparticles results in their aggregation, these results have important implications for the application of plasmonic metallic nanoparticles towards quantitative molecular imaging.

Paper Details

Date Published: 3 January 2013
PDF: 6 pages
J. Biomed. Opt. 18(1) 016001 doi: 10.1117/1.JBO.18.1.016001
Published in: Journal of Biomedical Optics Volume 18, Issue 1
Show Author Affiliations
Carolyn L. Bayer, The Univ. of Texas at Austin (United States)
Seung Yun Nam, The Univ. of Texas at Austin (United States)
Yun-Sheng Chen, The Univ. of Texas at Austin (United States)
Stanislav Y. Emelianov, The Univ. of Texas at Austin (United States)

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