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Journal of Biomedical Optics • Open Access

Light propagation in a turbid medium with insonified microbubbles
Author(s): Terence S. Leung; Jack E. Honeysett; Eleanor Stride; Jing Deng

Paper Abstract

Surfactant stabilized microbubbles are widely used clinical contrast agents for ultrasound imaging. In this work, the light propagation through a turbid medium in the presence of microbubbles has been investigated. Through a series of experiments, it has been found that the optical attenuation is increased when the microbubbles in a turbid medium are insonified by ultrasound. Such microbubble enhanced optical attenuation is a function of both applied ultrasound pressure and microbubble concentration. To understand the mechanisms involved, a Monte Carlo (MC) model has been developed. Under ultrasound exposure, the sizes of microbubbles vary in space and time, and their dynamics are modeled by the Rayleigh-Plesset equation. By using Mie theory, the spatially and temporally varying optical scattering and scattering efficiency of microbubbles are determined based on the bubble sizes and internal refractive indices. The MC model is shown to effectively describe a medium with rapidly changing optical scattering, and the results are validated against both computational results using an N-layered diffusion equation model and experimental results using a clinical microbubble contrast agent (SonoVue®).

Paper Details

Date Published: 4 January 2013
PDF: 9 pages
J. Biomed. Opt. 18(1) 015002 doi: 10.1117/1.JBO.18.1.015002
Published in: Journal of Biomedical Optics Volume 18, Issue 1
Show Author Affiliations
Terence S. Leung, Univ. College London (United Kingdom)
Jack E. Honeysett, Univ. College London (United Kingdom)
Eleanor Stride, Univ. of Oxford (United Kingdom)
Jing Deng, Univ. College London Hospitals NHS Foundation Trust (United Kingdom)

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