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Journal of Biomedical Optics • Open Access

Photoacoustic and ultrasound dual-modality imaging of human peripheral joints
Author(s): Guan Xu; Justin R. Rajian; Gandikota Girish; Mariana J. Kaplan; J. Brian Fowlkes; Paul L. Carson; Xueding Wang

Paper Abstract

A photoacoustic (PA) and ultrasound (US) dual modality system, for imaging human peripheral joints, is introduced. The system utilizes a commercial US unit for both US control imaging and PA signal acquisition. Preliminary in vivo evaluation of the system, on normal volunteers, revealed that this system can recover both the structural and functional information of intra- and extra-articular tissues. Confirmed by the control US images, the system, on the PA mode, can differentiate tendon from surrounding soft tissue based on the endogenous optical contrast. Presenting both morphological and pathological information in joint, this system holds promise for diagnosis and characterization of inflammatory joint diseases such as rheumatoid arthritis.

Paper Details

Date Published: 12 December 2012
PDF: 4 pages
J. Biomed. Opt. 18(1) 010502 doi: 10.1117/1.JBO.18.1.010502
Published in: Journal of Biomedical Optics Volume 18, Issue 1
Show Author Affiliations
Guan Xu, Univ. of Michigan Medical School (United States)
Justin R. Rajian, Univ. of Michigan Medical School (United States)
Gandikota Girish, Univ. of Michigan Medical School (United States)
Mariana J. Kaplan, Univ. of Michigan Medical School (United States)
J. Brian Fowlkes, Univ. of Michigan Medical School (United States)
Paul L. Carson, Univ. of Michigan Medical School (United States)
Xueding Wang, Univ. of Michigan Medical School (United States)


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