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Journal of Biomedical Optics

Fluorescence spectra of blood and urine for cervical cancer detection
Author(s): Vadivel Masilamani; Mohamad S. AlSalhi; Trinka Vijmasi; Kanaganaj Govindarajan; Ram Rathan Rai; Muhammad Atif; Saradh Prasad; Abdullah Aldwayyan
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Paper Abstract

In the current study, the fluorescence emission spectra (FES) and Stokes shift spectra (SSS) of blood and urine samples of cervical cancer patients were obtained and compared to those of normal controls. Both spectra showed that the relative intensity of biomolecules such as porphyrin, collagen, Nicotinamide adenine dinucleotide, and flavin were quite out of proportion in cervical cancer patients. The biochemical mechanism for the elevation of these fluorophores is not yet definitive; nevertheless, these biomolecules could serve as tumor markers for diagnosis, screening, and follow-up of cervical cancers. To the best of our knowledge, this is the first report on FES and SSS of blood and urine of cervical cancer patients to give a sensitivity of 80% and specificity of 78%.

Paper Details

Date Published: 6 September 2012
PDF: 6 pages
J. Biomed. Opt. 17(9) 098001 doi: 10.1117/1.JBO.17.9.098001
Published in: Journal of Biomedical Optics Volume 17, Issue 9
Show Author Affiliations
Vadivel Masilamani, King Saud Univ. (Saudi Arabia)
Mohamad S. AlSalhi, King Saud Univ. (Saudi Arabia)
Trinka Vijmasi, Thendrel Inc. (United States)
Kanaganaj Govindarajan, GVN Hospital (India)
Ram Rathan Rai, Rai Memorial Cancer Hospital (India)
Muhammad Atif, King Saud Univ. (Saudi Arabia)
Saradh Prasad, King Saud Univ. (Saudi Arabia)
Abdullah Aldwayyan, King Saud Univ. (Saudi Arabia)

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