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Journal of Biomedical Optics • Open Access

On the noninvasive optical monitoring and differentiation of methemoglobinemia and sulfhemoglobinemia
Author(s): Gladimir V. G. Baranoski; Tenn F. Chen; Bradley W. Kimmel; Erik Miranda; Daniel Yim

Paper Abstract

There are several pathologies whose study and diagnosis is impaired by a relatively small number of documented cases. A practical approach to overcome this obstacle and advance the research in this area consists in employing computer simulations to perform controlled in silico experiments. The results of these experiments, in turn, may be incorporated in the design of differential protocols for these pathologies. Accordingly, in this paper, we investigate the spectral responses of human skin affected by the presence of abnormal amounts of two dysfunctional hemoglobins, methemoglobin and sulfhemoglobin, which are associated with two life-threatening medical conditions, methemoglobinemia and sulfhemoglobinemia, respectively. We analyze the results of our in silico experiments and discuss their potential applications to the development of more effective noninvasive monitoring and differentiation procedures for these medical conditions.

Paper Details

Date Published: 12 September 2012
PDF: 14 pages
J. Biomed. Opt. 17(9) 097005 doi: 10.1117/1.JBO.17.9.097005
Published in: Journal of Biomedical Optics Volume 17, Issue 9
Show Author Affiliations
Gladimir V. G. Baranoski, Univ. of Waterloo (Canada)
Tenn F. Chen, Univ. of Waterloo (Canada)
Bradley W. Kimmel, Univ. of Waterloo (Canada)
Erik Miranda, Univ. of Waterloo (Canada)
Daniel Yim, Univ. of Waterloo (Canada)

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