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Journal of Biomedical Optics

In vivo functional imaging of blood flow and wall strain rate in outflow tract of embryonic chick heart using ultrafast spectral domain optical coherence tomography
Author(s): Peng Li; Ruikang K. Wang; Xin Yin; Liang Shi; Sandra Rugonyi
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Paper Abstract

During cardiac development, the cardiac wall and flowing blood are two important cardiac tissues that constantly interact with each other. This dynamic interaction defines appropriate biomechanical environment to which the embryonic heart is exposed. Quantitative assessment of the dynamic parameters of wall tissues and blood flow is required to further our understanding of cardiac development. We report the use of an ultrafast 1310-nm dual-camera spectral domain optical coherence tomography (SDOCT) system to characterize/image, in parallel, the dynamic radial strain rate of the myocardial wall and the Doppler velocity of the underlying flowing blood within an in vivo beating chick embryo. The OCT system operates at 184-kHz line scan rate, providing the flexibility of imaging the fast blood flow and the slow tissue deformation within one scan. The ability to simultaneously characterize tissue motion and blood flow provides a useful approach to better understand cardiac dynamics during early developmental stages.

Paper Details

Date Published: 6 September 2012
PDF: 8 pages
J. Biomed. Opt. 17(9) 096006 doi: 10.1117/1.JBO.17.9.096006
Published in: Journal of Biomedical Optics Volume 17, Issue 9
Show Author Affiliations
Peng Li, Univ. of Washington (United States)
Ruikang K. Wang, Univ. of Washington (United States)
Xin Yin, Oregon Health & Science Univ. (United States)
Liang Shi, Oregon Health & Science Univ. (United States)
Sandra Rugonyi, Oregon Health & Science Univ. (United States)

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