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Journal of Biomedical Optics • Open Access

Scattering anisotropy-weighted mesoscopic imaging
Author(s): Zhengbin Xu; Ally-Khan Somani; Young L. Kim

Paper Abstract

We report that when tissue images are formed via a small solid angle in the backward direction (i.e., back-directional gating), the image intensity is dominantly determined by tissue scattering anisotropy. Thus, this configuration allows for scattering anisotropy-weighted imaging that can provide an intrinsic contrast by capturing tissue structures and organizations. To demonstrate the immediate feasibility, we apply scattering anisotropy-weighted imaging to tissue blocks including basal-cell carcinomas as a pilot study. The main feature of our imaging approach is the high sensitivity to tumor locations and the simplicity for large-area visualization. We further envision that scattering anisotropy-weighted imaging could potentially be used to visualize tissue microenvironments in a mesoscopic (between microscopic and macroscopic) imaging setting.

Paper Details

Date Published: 6 September 2012
PDF: 3 pages
J. Biomed. Opt. 17(9) 090501 doi: 10.1117/1.JBO.17.9.090501
Published in: Journal of Biomedical Optics Volume 17, Issue 9
Show Author Affiliations
Zhengbin Xu, Purdue Univ. (United States)
Ally-Khan Somani, Indiana Univ. School of Medicine (United States)
Young L. Kim, Purdue Univ. (United States)

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