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Journal of Biomedical Optics

New noninvasive index for evaluation of the vascular age of healthy and sick people
Author(s): Ilya Fine; Alexander V. Kaminsky; Boris I. Kuznik; Elena M. Kustovsjya; Olga G. Maximova; Louis Shenkman
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Paper Abstract

We conducted a study on 861 healthy and sick subjects and demonstrated that some calculated parameters based on measurement of the dynamic light scattering (DLS) signal from the finger correlate highly with chronological age ranging from 1.5 to 85 years old. Measurements of DLS signals were obtained during both occlusion and nonocclusion of blood flow in the finger. For the nonocclusion case we found that the low-frequency component of the DLS signal significantly correlates with the biological age while the high-frequency component of the DLS signal resembles the arterial pulse-wave and does correlate with age. However, the most prominent correlation between the DLS characteristics and age was noted with the stasis stage measurements. We propose that the observed age-related phenomena are caused by alterations in local blood viscosity and interactions of the endothelial cells with erythrocytes. Further, a new noninvasive index based on the age-related optical characteristics was introduced. This noninvasive index may be used as a research and diagnostic tool to examine the endothelial and thrombolytic properties of the vascular system.

Paper Details

Date Published: 3 August 2012
PDF: 8 pages
J. Biomed. Opt. 17(8) 087002 doi: 10.1117/1.JBO.17.8.087002
Published in: Journal of Biomedical Optics Volume 17, Issue 8
Show Author Affiliations
Ilya Fine, Elfi-Tech Ltd. (Israel)
Alexander V. Kaminsky, Elfi-Tech Ltd. (Israel)
Boris I. Kuznik, Chita State Medical Academy (Russian Federation)
Elena M. Kustovsjya, Chita State Medical Academy (Russian Federation)
Olga G. Maximova, Chita State Medical Academy (Russian Federation)
Louis Shenkman, Tel Aviv Univ. (Israel)


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