Share Email Print

Journal of Biomedical Optics

Multimodal recording of brain activity in term newborns during photic stimulation by near-infrared spectroscopy and electroencephalography
Author(s): Martin Biallas; Ivo Trajkovic; Cornelia Hagmann; Felix Scholkmann; Carmen Jenny; Lisa Holper; Andreas Beck; Martin Wolf
Format Member Price Non-Member Price
PDF $20.00 $25.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

In this study 14 healthy term newborns (postnatal mean age 2.1 days) underwent photic stimulation during sleep on two different days. Near-infrared spectroscopy (NIRS) and electroencephalography (EEG) was acquired simultaneously. The aims of the study were: to determine (i) the sensitivity and (ii) the repeatability of NIRS to detect the hemodynamic response, (iii) the sensitivity and (iv) the repeatability of EEG to detect a visual evoked potential (VEP), (v) to analyze optical data for the optical neuronal signal, and (vi) to test whether inadequate stimulation could be reason for absent hemodynamic responses. The results of the study were as follows. (i) Sensitivity of NIRS was 61.5% to detect hemodynamic responses; (ii) their reproducibility was 41.7%. A VEP was detected (iii) in 96.3% of all subjects with (iv) a reproducibility of 92.3%. (v) In two measurements data met the criteria for an optical neuronal signal. The noise level was 9.6⋅10 −5 % change in optical density. (vi) Insufficient stimulation was excluded as reason for absent hemodynamic responses. We conclude that NIRS is an promising tool to study cognitive activation and development of the brain. For clinical application, however, the sensitivity and reproducibility on an individual level needs to be improved.

Paper Details

Date Published: 17 August 2012
PDF: 14 pages
J. Biomed. Opt. 17(8) 086011 doi: 10.1117/1.JBO.17.8.086011
Published in: Journal of Biomedical Optics Volume 17, Issue 8
Show Author Affiliations
Martin Biallas, Univ. Hospital Zürich (Switzerland)
Ivo Trajkovic, Univ. of Zürich (Switzerland)
Cornelia Hagmann, Univ. Hospital Zürich (Switzerland)
Felix Scholkmann, Univ. Hospital Zürich (Switzerland)
Carmen Jenny, Univ. Hospital Zürich (Switzerland)
Lisa Holper, Univ. Hospital Zürich (Switzerland)
Andreas Beck, Univ. of Basel (Switzerland)
Martin Wolf, Univ. Hospital Zürich (Switzerland)

© SPIE. Terms of Use
Back to Top