Share Email Print
cover

Journal of Biomedical Optics • Open Access

Micro-computed tomography-guided, non-equal voxel Monte Carlo method for reconstruction of fluorescence molecular tomography
Author(s): Guotao Quan; Kan Wang; Xiaoquan Yang; Yong Deng; Qingming Luo; Hui Gong

Paper Abstract

The study of dual-modality technology which combines microcomputed tomography (micro-CT) and fluorescence molecular tomography (FMT) has become one of the main focuses in FMT. However, because of the diversity of the optical properties and irregular geometry for small animals, a reconstruction method that can effectively utilize the high-resolution structural information of micro-CT for tissue with arbitrary optical properties is still one of the most challenging problems in FMT. We develop a micro-CT-guided non-equal voxel Monte Carlo method for FMT reconstruction. With the guidance of micro-CT, precise voxel binning can be conducted on the irregular boundary or region of interest. A modified Laplacian regularization method is also proposed to accurately reconstruct the distribution of the fluorescent yield for non-equal space voxels. Simulations and phantom experiments show that this method not only effectively reduces the loss of high-resolution structural information of micro-CT in irregular boundaries and increases the accuracy of the FMT algorithm in both forward and inverse problems, but the method also has a small Jacobian matrix and a short reconstruction time. At last, we performed small animal imaging to validate our method.

Paper Details

Date Published: 8 August 2012
PDF: 10 pages
J. Biomed. Opt. 17(8) 086006 doi: 10.1117/1.JBO.17.8.086006
Published in: Journal of Biomedical Optics Volume 17, Issue 8
Show Author Affiliations
Guotao Quan, Britton Chance Ctr. for Biomedical Photonics (China)
Kan Wang, Huazhong Univ. of Science and Technology (China)
Xiaoquan Yang, Huazhong Univ. of Science and Technology (China)
Yong Deng, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Huazhong Univ. of Science and Technology (China)
Hui Gong, Huazhong Univ. of Science and Technology (China)


© SPIE. Terms of Use
Back to Top