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Journal of Biomedical Optics

Micro-structured polymer scaffolds fabricated by direct laser writing for tissue engineering
Author(s): Paulius Danilevicius; Sima Rekštyte; Roaldas Gadonas; Mangirdas Malinauskas; Evaldas Balciunas; Rasa Jarasiene; Daiva Baltriukiene; Virginija Bukelskiene; Antanas Kraniauskas; Raimondas Sirmenis
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Paper Abstract

This work presents the latest results on direct laser writing of polymeric materials for tissue engineering applications. A femtosecond Yb:KGW laser (300 fs, 200 kHz, 515 nm) was used as a light source for non-linear lithography. Fabrication was implemented in various photosensitive polymeric materials, such as: hybrid organic-inorganic sol-gel based on silicon-zirconium oxides, commercial ORMOCER® class photoresins. These materials were structured via multi-photon polymerization technique with submicron resolution. Porous three-dimensional scaffolds for artificial tissue engineering were fabricated with constructed system and were up to several millimeters in overall size with 10 to 100 μm internal pores. Biocompatibility of the used materials was tested in primary rabbit muscle-derived stem cell culture in vitro and using laboratory rats in vivo. This interdisciplinary study suggests that proposed technique and materials are suitable for tissue engineering applications.

Paper Details

Date Published: 15 May 2012
PDF: 8 pages
J. Biomed. Opt. 17(8) 081405 doi: 10.1117/1.JBO.17.8.081405
Published in: Journal of Biomedical Optics Volume 17, Issue 8
Show Author Affiliations
Paulius Danilevicius, Vilnius Univ. (Lithuania)
Sima Rekštyte, Vilnius Univ. (Lithuania)
Roaldas Gadonas, Vilnius Univ. (Lithuania)
Mangirdas Malinauskas, Vilnius Univ. (Lithuania)
Evaldas Balciunas, Vilnius Univ. (Lithuania)
Rasa Jarasiene, Vilnius Univ. (Lithuania)
Daiva Baltriukiene, Vilnius Univ. (Lithuania)
Virginija Bukelskiene, Vilnius Univ. (Lithuania)
Antanas Kraniauskas, Vilnius Univ. Hospital (Lithuania)
Raimondas Sirmenis, Vilnius Univ. Hospital (Lithuania)


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