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Journal of Biomedical Optics

Hand-held optical imager (Gen-2): improved instrumentation and target detectability
Author(s): Jean Gonzalez; Joseph DeCerce; Sarah J. Erickson; Sergio L. Martinez; Annie Nunez; Manuela Roman; Barbara Traub; Cecilia A. Flores; Seigbeh M. Roberts; Estrella Hernandez; Wenceslao Aguirre; Anuradha Godavarty; Richard Kiszonas
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Paper Abstract

Hand-held optical imagers are developed by various researchers towards reflectance-based spectroscopic imaging of breast cancer. Recently, a Gen-1 handheld optical imager was developed with capabilities to perform two-dimensional (2-D) spectroscopic as well as three-dimensional (3-D) tomographic imaging studies. However, the imager was bulky with poor surface contact ( ∼ 30%) along curved tissues, and limited sensitivity to detect targets consistently. Herein, a Gen-2 hand-held optical imager that overcame the above limitations of the Gen-1 imager has been developed and the instrumentation described. The Gen-2 hand-held imager is less bulky, portable, and has improved surface contact ( ∼ 86%) on curved tissues. Additionally, the forked probe head design is capable of simultaneous bilateral reflectance imaging of both breast tissues, and also transillumination imaging of a single breast tissue. Experimental studies were performed on tissue phantoms to demonstrate the improved sensitivity in detecting targets using the Gen-2 imager. The improved instrumentation of the Gen-2 imager allowed detection of targets independent of their location with respect to the illumination points, unlike in Gen-1 imager. The developed imager has potential for future clinical breast imaging with enhanced sensitivity, via both reflectance and transillumination imaging.

Paper Details

Date Published: 15 May 2012
PDF: 10 pages
J. Biomed. Opt. 17(8) 081402 doi: 10.1117/1.JBO.17.8.081402
Published in: Journal of Biomedical Optics Volume 17, Issue 8
Show Author Affiliations
Jean Gonzalez, Florida International Univ. (United States)
Joseph DeCerce, Florida International Univ. (United States)
Sarah J. Erickson, Florida International Univ. (United States)
Sergio L. Martinez, Florida International Univ. (United States)
Annie Nunez, Florida International Univ. (United States)
Manuela Roman, Florida International Univ. (United States)
Barbara Traub, Florida International Univ. (United States)
Cecilia A. Flores, Florida International Univ. (United States)
Seigbeh M. Roberts, Florida International Univ. (United States)
Estrella Hernandez, Florida International Univ. (United States)
Wenceslao Aguirre, Florida International Univ. (United States)
Anuradha Godavarty, Florida International Univ. (United States)
Richard Kiszonas, Sylvester Comprehensive Cancer Ctr. (United States)


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