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Journal of Biomedical Optics

Reproducibility of near-infrared spectroscopy parameters measured during brachial artery occlusion and reactive hyperemia in healthy men
Author(s): Sebastien Lacroix; Mathieu Gayda; Vincent Gremeaux; Martin Juneau; Anil Nigam; Jean-Claude Tardif
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Paper Abstract

Near-infrared spectroscopy (NIRS) is a noninvasive technique evaluating microvascular function. The aim of this study was to assess the reproducibility of NIRS parameters during reactive hyperemia induced by a 5 min brachial artery occlusion. Twenty-four healthy young males (mean 34±8 years old) had two microvascular function evaluations by NIRS over a 7 to 30-day period (mean 16±10 days). Intra-subject and inter-observer reproducibility were evaluated with intraclass correlation coefficient (ICC), coefficient of variation (CV), and standard error of measurement (SEM%) for every parameter. Mean NIRS parameters did not differ between both evaluations. Reproducibility was greatest for muscle oxygen consumption (ICC: 0.84; CV: 6.51%; SEM: 7.11%), time to basal O2Hb (ICC: 0.63, CV: 20.04%, SEM 27.22%), time to maximal O2Hb (ICC: 0.71; CV: 15.61%; SEM: 19.27%), peak of O2Hb (ICC: 0.63, CV: 6.68%, SEM 8.53%), time to maximal tHb (ICC: 0.73, CV: 19,61%, SEM 24.56%) and area under the O2Hb and tHb curves (ICC: 0.68, CV: 16.15%, SEM 22.93% and ICC: 0.62, CV: 18.59%, SEM 26.64%, respectively). Moreover, inter-observer reproducibility ranged from excellent to perfect (ICC from 0.85 to 1.00) for every parameter. NIRS parameters during reactive hyperemia are highly reproducible which enables their repeated measurement to study microvascular function in healthy subjects.

Paper Details

Date Published: 17 July 2012
PDF: 6 pages
J. Biomed. Opt. 17(7) 077010 doi: 10.1117/1.JBO.17.7.077010
Published in: Journal of Biomedical Optics Volume 17, Issue 7
Show Author Affiliations
Sebastien Lacroix, Montréal Heart Institute (Canada)
Mathieu Gayda, Montréal Heart Institute (Canada)
Vincent Gremeaux, Montréal Heart Institute (Canada)
Martin Juneau, Montréal Heart Institute (Canada)
Anil Nigam, Montréal Heart Institute (Canada)
Jean-Claude Tardif, Montréal Heart Institute (Canada)


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