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Journal of Biomedical Optics • Open Access

Noninvasive evaluation of collagen and hemoglobin contents and scattering property of in vivo keloid scars and normal skin using diffuse reflectance spectroscopy: pilot study
Author(s): Sheng-Hao Tseng; Shih-Yu Tzeng; Yu-Kai Liaw; Chao-Kai Hsu; Julia Lee; Wan-Rung Chen

Paper Abstract

Collagen is a rich component in skin that provides skin structure integrity; however, its contribution to the absorption and scattering properties of various types of skin has not been extensively studied. We considered the contribution of the collagen to the absorption spectrum of in vivo normal skin and keloids of 12 subjects derived from our diffuse reflectance spectroscopy (DRS) system in the wavelength range from 550 to 860 nm. It was found that the collagen concentration, the hemoglobin oxygen saturation, and the reduced scattering coefficient of keloids were remarkably different from that of normal skin. Our results suggest that our DRS system could assist clinicians in understanding the functional and structural condition of keloid scars. In the future, we will evaluate the accuracy of our system in the keloid diagnosis and investigate the applicability of our system for other skin-collagen-related studies.

Paper Details

Date Published: 18 July 2012
PDF: 12 pages
J. Biomed. Opt. 17(7) 077005 doi: 10.1117/1.JBO.17.7.077005
Published in: Journal of Biomedical Optics Volume 17, Issue 7
Show Author Affiliations
Sheng-Hao Tseng, National Cheng Kung Univ. (Taiwan)
Shih-Yu Tzeng, National Cheng Kung Univ. (Taiwan)
Yu-Kai Liaw, National Cheng Kung Univ. (Taiwan)
Chao-Kai Hsu, National Cheng Kung Univ. (Taiwan)
Julia Lee, National Cheng Kung Univ. (Taiwan)
Wan-Rung Chen, National Cheng Kung Univ. (Taiwan)

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