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Journal of Biomedical Optics

Frequency domain multiplexing for speckle reduction in optical coherence tomography
Author(s): Gijs van Soest; Evelyn Regar; Antonius F. W. van der Steen; Martin L. Villiger; Guillermo J. Tearney; Brett E. Bouma
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Paper Abstract

Quantitative analysis of optical coherence tomography data can be strongly hampered by speckle. Here, we introduce a new method to reduce speckle, which leverages from Fourier-domain configurations and operates on individual axial scans. By subdividing the digitized spectrum into a number of distinct narrower windows, each with a different center frequency, several independent speckle patterns result. These can be averaged to yield a lower-resolution image with strongly reduced speckle. The full resolution image remains available for human interpretation; the low resolution version can be used for parametric imaging or quantitative analysis. We demonstrate this technique using intravascular optical frequency domain imaging data acquired in vivo.

Paper Details

Date Published: 13 July 2012
PDF: 8 pages
J. Biomed. Opt. 17(7) 076018 doi: 10.1117/1.JBO.17.7.076018
Published in: Journal of Biomedical Optics Volume 17, Issue 7
Show Author Affiliations
Gijs van Soest, Erasmus MC (Netherlands)
Evelyn Regar, Erasmus MC (Netherlands)
Antonius F. W. van der Steen, Erasmus MC (Netherlands)
Martin L. Villiger, Wellman Ctr. for Photomedicine (United States)
Guillermo J. Tearney, Wellman Ctr. for Photomedicine (United States)
Brett E. Bouma, Wellman Ctr. for Photomedicine (United States)

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