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Journal of Biomedical Optics

Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography
Author(s): Muhammad R. Chatni; Jun Xia; Konstantin I. Maslov; Zijian Guo; Kun Wang; Mark A. Anastasio; Lihong V. Wang; Rebecca Sohn; Jeffrey M. Arbeit; Yu Zhang; Younan Xia
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Paper Abstract

With the increasing use of small animals for human disease studies, small-animal whole-body molecular imaging plays an important role in biomedical research. Currently, none of the existing imaging modalities can provide both anatomical and glucose molecular information, leading to higher costs of building dual-modality systems. Even with image co-registration, the spatial resolution of the molecular imaging modality is not improved. Utilizing a ring-shaped confocal photoacoustic computed tomography system, we demonstrate, for the first time, that both anatomy and glucose uptake can be imaged in a single modality. Anatomy was imaged with the endogenous hemoglobin contrast, and glucose metabolism was imaged with a near-infrared dye-labeled 2-deoxyglucose.

Paper Details

Date Published: 6 July 2012
PDF: 8 pages
J. Biomed. Opt. 17(7) 076012 doi: 10.1117/1.JBO.17.7.076012
Published in: Journal of Biomedical Optics Volume 17, Issue 7
Show Author Affiliations
Muhammad R. Chatni, Washington Univ. in St. Louis (United States)
Jun Xia, Washington Univ. in St. Louis (United States)
Konstantin I. Maslov, Washington Univ. in St. Louis (United States)
Zijian Guo, Washington Univ. in St. Louis (United States)
Kun Wang, Washington Univ. in St. Louis (United States)
Mark A. Anastasio, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)
Rebecca Sohn, Washington Univ. in St. Louis (United States)
Jeffrey M. Arbeit, Washington Univ. in St. Louis (United States)
Yu Zhang, Georgia Institute of Technology (United States)
Younan Xia, Georgia Institute of Technology (United States)


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