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Journal of Biomedical Optics • Open Access

Diffuse optical imaging using spatially and temporally modulated light
Author(s): Thomas D. O'Sullivan; Albert E. Cerussi; Bruce J. Tromberg; David J. Cuccia

Paper Abstract

The authors describe the development of diffuse optical imaging (DOI) technologies, specifically the use of spatial and temporal modulation to control near infrared light propagation in thick tissues. We present theory and methods of DOI focusing on model-based techniques for quantitative, in vivo measurements of endogenous tissue absorption and scattering properties. We specifically emphasize the common conceptual framework of the scalar photon density wave for both temporal and spatial frequency-domain approaches. After presenting the history, theoretical foundation, and instrumentation related to these methods, we provide a brief review of clinical and preclinical applications from our research as well as our outlook on the future of DOI technology.

Paper Details

Date Published: 18 July 2012
PDF: 15 pages
J. Biomed. Opt. 17(7) 071311 doi: 10.1117/1.JBO.17.7.071311
Published in: Journal of Biomedical Optics Volume 17, Issue 7
Show Author Affiliations
Thomas D. O'Sullivan, Univ. of California, Irvine (United States)
Albert E. Cerussi, Beckman Laser Institute and Medical Clinic (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)
David J. Cuccia, Modulated Imaging, Inc. (United States)


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