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Journal of Biomedical Optics

Tissue surface as the reference arm in Fourier domain optical coherence tomography
Author(s): Nikola Krstajic; Christian T. A. Brown; Kishan Dholakia; Mario E. Giardini
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Paper Abstract

We present a simple method applicable to common-path Fourier domain optical coherence tomography (OCT) in which the tissue surface is used as the reference arm. We propose using aluminium hydroxide powder as a potential tissue surface diffuser to allow wider application of this method. This technique allows one to avoid placing a reference arm reflective element, such as glass plate, on tissue, and intrinsically avoids both coherent and complex conjugate mirror artifacts associated with glass plates. Aluminium hydroxide can be sprayed onto tissue using spray nozzles commonly found in endoscopes. The sensitivity of the tissue reference arm common-path OCT image is 94 dB for a 50-µs charge-coupled device integration time, and 97.5 dB for a 200-µs CCD integration time.

Paper Details

Date Published: 15 May 2012
PDF: 7 pages
J. Biomed. Opt. 17(7) 071305 doi: 10.1117/1.JBO.17.7.071305
Published in: Journal of Biomedical Optics Volume 17, Issue 7
Show Author Affiliations
Nikola Krstajic, The Univ. of Edinburgh (United Kingdom)
Christian T. A. Brown, Univ. of St. Andrews (United Kingdom)
Kishan Dholakia, Univ. of St. Andrews (United Kingdom)
Mario E. Giardini, Univ. of St. Andrews (United Kingdom)


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