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Journal of Biomedical Optics • Open Access

Ultrahigh-speed non-invasive widefield angiography
Author(s): Cedric Blatter; Branislav Grajciar; Tilman Schmoll; Rainer A. Leitgeb; Thomas Klein; Wolfgang Wieser; Raphael J. André; Robert Huber

Paper Abstract

Retinal and choroidal vascular imaging is an important diagnostic benefit for ocular diseases such as age-related macular degeneration. The current gold standard for vessel visualization is fluorescence angiography. We present a potential non-invasive alternative to image blood vessels based on functional Fourier domain optical coherence tomography (OCT). For OCT to compete with the field of view and resolution of angiography while maintaining motion artifacts to a minimum, ultrahigh-speed imaging has to be introduced. We employ Fourier domain mode locking swept source technology that offers high quality imaging at an A-scan rate of up to 1.68 MHz. We present retinal angiogram over ∼ 48  deg acquired in a few seconds in a single recording without the need of image stitching. OCT at 1060 nm allows for high penetration in the choroid and efficient separate characterization of the retinal and choroidal vascularization.

Paper Details

Date Published: 29 June 2012
PDF: 4 pages
J. Biomed. Opt. 17(7) 070505 doi: 10.1117/1.JBO.17.7.070505
Published in: Journal of Biomedical Optics Volume 17, Issue 7
Show Author Affiliations
Cedric Blatter, Medizinische Univ. Wien (Austria)
Branislav Grajciar, Medizinische Univ. Wien (Austria)
Tilman Schmoll, Medizinische Univ. Wien (Austria)
Rainer A. Leitgeb, Medizinische Univ. Wien (Austria)
Thomas Klein, Ludwig-Maximilians-Univ. München (Germany)
Wolfgang Wieser, Ludwig-Maximilians-Univ. München (Germany)
Raphael J. André, Ludwig-Maximilians-Univ. München (Germany)
Robert Huber, Ludwig-Maximilians-Univ. München (Germany)

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