Share Email Print
cover

Journal of Biomedical Optics • Open Access

Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner
Author(s): Shanshan Liang; Changsen Sun; Arya Saidi; Joseph Jing; Gangjun Liu; Jiawen Li; Jun Zhang; Zhongping Chen; Jagat Narula

Paper Abstract

We developed a multimodality fluorescence and optical coherence tomography probe based on a double-clad fiber (DCF) combiner. The probe is composed of a DCF combiner, grin lens, and micromotor in the distal end. An integrated swept-source optical coherence tomography and fluorescence intensity imaging system was developed based on the combined probe for the early diagnoses of atherosclerosis. This system is capable of real-time data acquisition and processing as well as image display. For fluorescence imaging, the inflammation of atherosclerosis and necrotic core formed with the annexin V-conjugated Cy5.5 were imaged. Ex vivo imaging of New Zealand white rabbit arteries demonstrated the capability of the combined system.

Paper Details

Date Published: 28 June 2012
PDF: 4 pages
J. Biomed. Opt. 17(7) 070501 doi: 10.1117/1.JBO.17.7.070501
Published in: Journal of Biomedical Optics Volume 17, Issue 7
Show Author Affiliations
Shanshan Liang, Dalian Univ. of Technology (China)
Changsen Sun, Dalian Univ. of Technology (China)
Arya Saidi, Beckman Laser Institute and Medical Clinic (United States)
Joseph Jing, Univ. of California, Irvine (United States)
Gangjun Liu, Beckman Laser Institute and Medical Clinic (United States)
Jiawen Li, Univ. of California, Irvine (United States)
Jun Zhang, Beckman Laser Institute and Medical Clinic (United States)
Zhongping Chen, Beckman Laser Institute and Medical Clinic (United States)
Jagat Narula, Univ. of California, Irvine (United States)


© SPIE. Terms of Use
Back to Top