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Journal of Biomedical Optics

New optional photodynamic therapy laser wavelength for infantile port wine stains: 457 nm
Author(s): Ying Wang; Zhaohui Zuo; Ying Gu; Naiyan Huang; Rong Chen; Buhong Li; Haixia Qiu; Jing Zeng; Jianguo Zhu; Jie Liang
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Paper Abstract

To expand the optional laser wavelengths of photodynamic therapy (PDT) for port wine stain (PWS), the feasibility of applying a 457 nm laser to the PDT for infantile PWS was analyzed by mathematical simulation and was validated by clinical experiment. Singlet oxygen yield of 457 nm PDT or 532 nm PDT in an infantile PWS model and an adult PWS model was theoretically simulated. Fifteen PWS patients (14 infants and 1 adult) with 40 spots were treated with 457 nm (20 spots) and 532 nm (20 spots), respectively, in two PDT courses. Simulation results showed that under the same power density and irradiation time, singlet oxygen yield of 457 nm PDT and 532 nm PDT are similar in infantile PWS vessels. Yet, in adult PWS vessels, singlet oxygen yield of 457 nm PDT is lower than 532 nm PDT. Clinical outcomes showed that no statistic difference existed between 457 nm PDT and 532 nm PDT for infantile PWS. The result of this study suggested that 457 nm wavelength laser has the potential to be applied in PDT for infantile PWS.

Paper Details

Date Published: 6 June 2012
PDF: 6 pages
J. Biomed. Opt. 17(6) 068003 doi: 10.1117/1.JBO.17.6.068003
Published in: Journal of Biomedical Optics Volume 17, Issue 6
Show Author Affiliations
Ying Wang, Chinese PLA General Hospital (China)
Zhaohui Zuo, Beijing Shuguang Aerospace Electrical Co. Ltd (China)
Ying Gu, Chinese PLA General Hospital (China)
Naiyan Huang, Chinese PLA General Hospital (China)
Rong Chen, Fujian Normal Univ. (China)
Buhong Li, Fujian Normal Univ. (China)
Haixia Qiu, Chinese PLA General Hospital (China)
Jing Zeng, Chinese PLA General Hospital (China)
Jianguo Zhu, Chinese PLA General Hospital (China)
Jie Liang, Chinese PLA General Hospital (China)

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