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Journal of Biomedical Optics

On-chip digital microfluidic architectures for enhanced actuation and sensing
Author(s): Jacqueline A. Nichols; Christopher M. Collier; Emily L. Landry; Michael Wiltshire; Brandon Born; Jonathan F. Holzman
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Paper Abstract

An on-chip system is presented with integrated architectures for digital microfluidic actuation and sensing. Localized actuation is brought about by a digital microfluidic multiplexer layout that overcomes the challenges of multi-microdrop interference, and complete two-dimensional motion is shown for microdrops on a 14×14 grid with minimized complexity by way of 14+14 inputs. At the same time, microdrop sensing is demonstrated in a folded-cavity design for enhanced optical intensity probing of internal fluid refractive indices. The heightened intensities from this on-chip refractometer are shown to have a linear response to the underlying fluid refractive index. An electro-dispensing technique is used to fabricate the folded-cavity optical architecture in a format that is tuned for the desired refractive index range and sensitivity. The overall lab-on-a-chip system is successful in integrating localized microdrop actuation and sensing.

Paper Details

Date Published: 11 June 2012
PDF: 8 pages
J. Biomed. Opt. 17(6) 067005 doi: 10.1117/1.JBO.17.6.067005
Published in: Journal of Biomedical Optics Volume 17, Issue 6
Show Author Affiliations
Jacqueline A. Nichols, UBC Okanagan (Canada)
Christopher M. Collier, UBC Okanagan (Canada)
Emily L. Landry, UBC Okanagan (Canada)
Michael Wiltshire, UBC Okanagan (Canada)
Brandon Born, UBC Okanagan (Canada)
Jonathan F. Holzman, UBC Okanagan (Canada)

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