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Journal of Biomedical Optics • Open Access

Joint derivation method for determining optical properties based on steady-state spatially resolved diffuse reflectance measurement at small source-detector separations and large reduced albedo range: theory and simulation
Author(s): Zhenzhi Shi; Ying Fan; Huijuan Zhao; Kexin Xu

Paper Abstract

Accurate determination of the optical properties (the absorption coefficient μa and the reduced scattering coefficient μs′) of tissues is very important in a variety of diagnostic and therapeutic procedures. Optical diffusion theory is frequently used as the forward model for describing the photon transfer in media with large reduced albedos (a′) and in large source-detector separations (SDS). Several other methods (PN approximation, hybrid diffusion-P3 approximation) have also been published that describe photon transfer in media with low a′ or small SDSs. We studied the theoretical models for the steady-state spatially resolved diffuse reflectance measurement to accurately determine μa and μs′ at large a′ range but small SDSs. Instead of using a single model, a joint derivation method is proposed. The developed method uses one of the best aforementioned theoretical methods separately in five ranges of a′ determined from several forward models. In the region of small SDSs (the range between 0.4 and 8 mm) and large a′ range (between 0.5 and 0.99), the best theoretical derivation model was determined. The results indicate that the joint derivation method can improve the derivation accuracy and that a′ range can be determined by the steady-state spatially resolved diffuse reflectance measurement.

Paper Details

Date Published: 6 June 2012
PDF: 12 pages
J. Biomed. Opt. 17(6) 067004 doi: 10.1117/1.JBO.17.6.067004
Published in: Journal of Biomedical Optics Volume 17, Issue 6
Show Author Affiliations
Zhenzhi Shi, Tianjin Univ. (China)
Ying Fan, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)
Kexin Xu, Tianjin Univ. (China)

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