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Journal of Biomedical Optics • Open Access

Joint derivation method for determining optical properties based on steady-state spatially resolved diffuse reflectance measurement at small source-detector separations and large reduced albedo range: theory and simulation
Author(s): Zhenzhi Shi; Ying Fan; Huijuan Zhao; Kexin Xu

Paper Abstract

Accurate determination of the optical properties (the absorption coefficient μa and the reduced scattering coefficient μs′) of tissues is very important in a variety of diagnostic and therapeutic procedures. Optical diffusion theory is frequently used as the forward model for describing the photon transfer in media with large reduced albedos (a  ′  ) and in large source-detector separations (SDS). Several other methods (PN approximation, hybrid diffusion-P3 approximation) have also been published that describe photon transfer in media with low a  ′   or small SDSs. We studied the theoretical models for the steady-state spatially resolved diffuse reflectance measurement to accurately determine μa and μs′ at large a  ′   range but small SDSs. Instead of using a single model, a joint derivation method is proposed. The developed method uses one of the best aforementioned theoretical methods separately in five ranges of a  ′   determined from several forward models. In the region of small SDSs (the range between 0.4 and 8 mm) and large a  ′   range (between 0.5 and 0.99), the best theoretical derivation model was determined. The results indicate that the joint derivation method can improve the derivation accuracy and that a  ′   range can be determined by the steady-state spatially resolved diffuse reflectance measurement.

Paper Details

Date Published: 6 June 2012
PDF: 11 pages
J. Biomed. Opt. 17(6) 067004 doi: 10.1117/1.JBO.17.6.067004
Published in: Journal of Biomedical Optics Volume 17, Issue 6
Show Author Affiliations
Zhenzhi Shi, Tianjin Univ. (China)
Ying Fan, Tianjin Univ. (China)
Huijuan Zhao, Tianjin Univ. (China)
Kexin Xu, Tianjin Univ. (China)

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