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Journal of Biomedical Optics • Open Access

Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging
Author(s): Xiang Wen; Dan Zhu; Steven L. Jacques; Valery V. Tuchin

Paper Abstract

The strong optical scattering of skin tissue makes it very difficult for optical coherence tomography (OCT) to achieve deep imaging in skin. Significant optical clearing of in vivo rat skin sites was achieved within 15 min by topical application of an optical clearing agent PEG-400, a chemical enhancer (thiazone or propanediol), and physical massage. Only when all three components were applied together could a 15 min treatment achieve a three fold increase in the OCT reflectance from a 300 μm depth and 31% enhancement in image depth Zthreshold.

Paper Details

Date Published: 13 June 2012
PDF: 7 pages
J. Biomed. Opt. 17(6) 066022 doi: 10.1117/1.JBO.17.6.066022
Published in: Journal of Biomedical Optics Volume 17, Issue 6
Show Author Affiliations
Xiang Wen, Britton Chance Ctr. for Biomedical Photonics (China)
Dan Zhu, Huazhong Univ. of Science and Technology (China)
Steven L. Jacques, Oregon Health & Science Univ. (United States)
Valery V. Tuchin, N.G. Chernyshevsky Saratov State Univ. (Russian Federation)


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