Share Email Print
cover

Journal of Biomedical Optics

Quantitative analysis of the intraretinal layers and optic nerve head using ultra-high resolution optical coherence tomography
Author(s): Yuhong Wang; Meixiao Shen; Ming Li; Aizhu Tao; Yilei Shao; Hong Jiang; Byron L. Lam; Delia Cabrera DeBuc; Jianhua Wang; Yufeng Ye
Format Member Price Non-Member Price
PDF $20.00 $25.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

This study is designed to test the repeatability of the quantitative analysis of intraretinal layer thickness and cup-disc ratio of the optic nerve head using ultra-high resolution optical coherence tomography (UHR-OCT). Group A, containing 23 eyes of 12 healthy subjects, was imaged twice and group B, containing eight eyes of four subjects, was imaged three times. Intraretinal layers were segmented manually and the cup-to-disc ratio of the optic nerve head was analyzed. Custom-built automatic segmentation software was also used to segment a set of images for comparison. A total of nine intraretinal layers were visualized and extracted manually. With group A, the central foveal thickness was 186.4±15.9  μm (mean±SD). The average retinal thickness was 296.4±21.3  μm. The best repeatability, obtained when two repeated scans were taken, was obtained for the outer nuclear layer followed by the ganglion cell layer, the inner nuclear layer, the retinal nerve fiber layer and the worst was obtained for the outer segment. The intraclass correlation ranged from 0.824 to 0.997. The coefficients of repeatability ranged from 3.24 to 18.3  μm, corresponding to 1.47% to 26.20%. With group B, high interclass correlations were found and the automatic segmentation results were compatible with the manual results. Our results indicated that more retinal features might be imageable using UHR-OCT.

Paper Details

Date Published: 4 June 2012
PDF: 10 pages
J. Biomed. Opt. 17(6) 066013 doi: 10.1117/1.JBO.17.6.066013
Published in: Journal of Biomedical Optics Volume 17, Issue 6
Show Author Affiliations
Yuhong Wang, Wenzhou Medical College (China)
Meixiao Shen, Wenzhou Medical College (China)
Ming Li, Wenzhou Medical College (China)
Aizhu Tao, Wenzhou Medical College (China)
Yilei Shao, Wenzhou Medical College (China)
Hong Jiang, Bascom Palmer Eye Institute (United States)
Byron L. Lam, Bascom Palmer Eye Institute (United States)
Delia Cabrera DeBuc, Bascom Palmer Eye Institute (United States)
Jianhua Wang, Bascom Palmer Eye Institute (United States)
Yufeng Ye, Hangzhou First People's Hospital (China)


© SPIE. Terms of Use
Back to Top