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Journal of Biomedical Optics

<italic<In situ</italic< gold nanoparticles formation: contrast agent for dental optical coherence tomography
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Paper Abstract

In this work we demonstrate the potential use of gold nanoparticles as contrast agents for the optical coherence tomography (OCT) imaging technique in dentistry. Here, a new <italic<in situ</italic< photothermal reduction procedure was developed, producing spherical gold nanoparticles inside dentinal layers and tubules. Gold ions were dispersed in the primer of commercially available dental bonding systems. After the application and permeation in dentin by the modified adhesive systems, the dental bonding materials were photopolymerized concurrently with the formation of gold nanoparticles. The gold nanoparticles were visualized by scanning electron microscopy (SEM). The SEM images show the presence of gold nanospheres in the hybrid layer and dentinal tubules. The diameter of the gold nanoparticles was determined to be in the range of 40 to 120 nm. Optical coherence tomography images were obtained in two- and three-dimensions. The distribution of nanoparticles was analyzed and the extended depth of nanosphere production was determined. The results show that the OCT technique, using <italic<in situ</italic< formed gold nanoparticles as contrast enhancers, can be used to visualize dentin structures in a non-invasive and non-destructive way.

Paper Details

Date Published: 5 June 2012
PDF: 6 pages
J. Biomed. Opt. 17(6) 066003 doi: 10.1117/1.JBO.17.6.066003
Published in: Journal of Biomedical Optics Volume 17, Issue 6
Show Author Affiliations
Ana Karla S. Braz, Univ. Federal de Pernambuco (Brazil)
Renato E. de Araujo, Univ. Federal de Pernambuco (Brazil)
Tymish Y. Ohulchanskyy, Univ. at Buffalo (United States)
Shoba Shukla, Univ. at Buffalo (United States)
Earl J. Bergey, Univ. at Buffalo (United States)
Anderson S. Gomes, Univ. Federal de Pernambuco (Brazil)
Paras N. Prasad, Univ. at Buffalo (United States)

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