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Journal of Biomedical Optics • Open Access

Suppression of background signal in magnetomotive photoacoustic imaging of magnetic microspheres mimicking targeted cells
Author(s): Jinjun Xia; Ivan M. Pelivanov; Chen-Wei Wei; Xiaoge Hu; Xiaohu Gao; Matthew O'Donnell

Paper Abstract

Contrast-enhanced photoacoustic (PA) imaging has been proposed to identify circulating metastatic cancer cells magnetically trapped in the vasculature. However, its sensitivity is limited by the presence of a strong blood-background signal. This technique can be further improved by the significant suppression of blood background. In the phantom study presented here, significant background suppression is demonstrated with magnetomotive photoacoustic imaging. Magnetic particles with a mean diameter of 10 μm were integrated (concentration of 0.05  mg/ml) into an ink-water solution with an optical absorption coefficient of 5  cm−1 to mimic cells targeted with magnetic nanoparticles and magnetically trapped in the human vasculature. Two mechanically moveable permanent magnets were used to accumulate microparticles in the investigated solution and manipulate them within a thin, 1.6-mm-diameter Teflon tube mimicking a blood vessel. Our results clearly indicate that the undesirable background can be effectively suppressed using the difference of PA images corresponding to different locations of accumulated particles.

Paper Details

Date Published: 14 May 2012
PDF: 7 pages
J. Biomed. Opt. 17(6) 061224 doi: 10.1117/1.JBO.17.6.061224
Published in: Journal of Biomedical Optics Volume 17, Issue 6
Show Author Affiliations
Jinjun Xia, Univ. of Washington (United States)
Ivan M. Pelivanov, Univ. of Washington (United States)
Chen-Wei Wei, Univ. of Washington (United States)
Xiaoge Hu, Univ. of Washington (United States)
Xiaohu Gao, Univ. of Washington (United States)
Matthew O'Donnell, Univ. of Washington (United States)

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