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Journal of Biomedical Optics

Determination of optical absorption coefficient with focusing photoacoustic imaging
Author(s): Zhifang Li; Hui Li; Zhiping Zeng; Wenming Xie; Wei R. Chen
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Paper Abstract

Absorption coefficient of biological tissue is an important factor for photothermal therapy and photoacoustic imaging. However, its determination remains a challenge. In this paper, we propose a method using focusing photoacoustic imaging technique to quantify the target optical absorption coefficient. It utilizes the ratio of the amplitude of the peak signal from the top boundary of the target to that from the bottom boundary based on wavelet transform. This method is self-calibrating. Factors, such as absolute optical fluence, ultrasound parameters, and Grüneisen parameter, can be canceled by dividing the amplitudes of the two peaks. To demonstrate this method, we quantified the optical absorption coefficient of a target with various concentrations of an absorbing dye. This method is particularly useful to provide accurate absorption coefficient for predicting the outcomes of photothermal interaction for cancer treatment with absorption enhancement.

Paper Details

Date Published: 21 May 2012
PDF: 7 pages
J. Biomed. Opt. 17(6) 061216 doi: 10.1117/1.JBO.17.6.061216
Published in: Journal of Biomedical Optics Volume 17, Issue 6
Show Author Affiliations
Zhifang Li, Fujian Normal Univ. (China)
Hui Li, Fujian Normal Univ. (China)
Zhiping Zeng, Fujian Normal Univ. (China)
Wenming Xie, Fujian Normal Univ. (China)
Wei R. Chen, Univ. of Central Oklahoma (United States)

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