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Journal of Biomedical Optics

In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe
Author(s): Yu Wang; Zijian Guo; Lihong V. Wang; Todd N. Erpelding; Ladislav Jankovic; Jean-Luc Robert; Guillaume David
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Paper Abstract

We present an integrated photoacoustic and ultrasonic three-dimensional (3-D) volumetric imaging system based on a two-dimensional (2-D) matrix array ultrasound probe. A wavelength-tunable dye laser pumped by a Q-switched Nd:YAG laser serves as the light source and a modified commercial ultrasound imaging system (iU22, Philips Healthcare) with a 2-D array transducer (X7-2, Philips Healthcare) detects both the pulse-echo ultrasound and photoacoustic signals. A multichannel data acquisition system acquires the RF channel data. The imaging system enables rendering of co-registered 3-D ultrasound and photoacoustic images without mechanical scanning. The resolution along the azimuth, elevation, and axial direction are measured to be 0.69, 0.90 and 0.84 mm for photoacoustic imaging. In vivo 3-D photoacoustic mapping of the sentinel lymph node was demonstrated in a rat model using methylene blue dye. These results highlight the clinical potential of 3-D PA imaging for identification of sentinel lymph nodes for cancer staging in humans.

Paper Details

Date Published: 7 May 2012
PDF: 6 pages
J. Biomed. Opt. 17(6) 061208 doi: 10.1117/1.JBO.17.6.061208
Published in: Journal of Biomedical Optics Volume 17, Issue 6
Show Author Affiliations
Yu Wang, Washington Univ. in St. Louis (United States)
Zijian Guo, Washington Univ. in St. Louis (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)
Todd N. Erpelding, Philips Research North America (United States)
Ladislav Jankovic, Philips Research North America (United States)
Jean-Luc Robert, Philips Research North America (United States)
Guillaume David, Philips Research North America (United States)


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