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Journal of Biomedical Optics

Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform
Author(s): Wei Song; Qing Wei; Tan Liu; David Kuai; Hao F. Zhang; Janice M. Burke; Shuliang Jiao
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Paper Abstract

Photoacoustic ophthalmoscopy (PAOM) is a newly developed retinal imaging technology that holds promise for both fundamental investigation and clinical diagnosis of several blinding diseases. Hence, integrating PAOM with other existing ophthalmic imaging modalities is important to identify and verify the strengths of PAOM compared with the established technologies and to provide the foundation for more comprehensive multimodal imaging. To this end, we developed a retinal imaging platform integrating PAOM with scanning laser ophthalmoscopy (SLO), spectral-domain optical coherence tomography (SD-OCT), and fluorescein angiography (FA). In the system, all the imaging modalities shared the same optical scanning and delivery mechanisms, which enabled registered retinal imaging from all the modalities. High-resolution PAOM, SD-OCT, SLO, and FA images were acquired in both albino and pigmented rat eyes. The reported in vivo results demonstrate the capability of the integrated system to provide comprehensive anatomic imaging based on multiple optical contrasts.

Paper Details

Date Published: 7 May 2012
PDF: 8 pages
J. Biomed. Opt. 17(6) 061206 doi: 10.1117/1.JBO.17.6.061206
Published in: Journal of Biomedical Optics Volume 17, Issue 6
Show Author Affiliations
Wei Song, Northwestern Univ. (United States)
Qing Wei, Northwestern Univ. (United States)
Tan Liu, Northwestern Univ. (United States)
David Kuai, Northwestern Univ. (United States)
Hao F. Zhang, Northwestern Univ. (United States)
Janice M. Burke, Medical College of Wisconsin (United States)
Shuliang Jiao, The Univ. of Southern California (United States)

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