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Journal of Biomedical Optics

Photoacoustic-guided ultrasound therapy with a dual-mode ultrasound array
Author(s): Amaury Prost; Arik R. Funke; Mickael Tanter; Jean-François Aubry; Emmanuel Bossy
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Paper Abstract

Photoacoustics has recently been proposed as a potential method to guide and/or monitor therapy based on high-intensity focused ultrasound (HIFU). We experimentally demonstrate the creation of a HIFU lesion at the location of an optical absorber, by use of photoacoustic signals emitted by the absorber detected on a dual mode transducer array. To do so, a dedicated ultrasound array intended to both detect photoacoustic waves and emit HIFU with the same elements was used. Such a dual-mode array provides automatically coregistered reference frames for photoacoustic detection and HIFU emission, a highly desired feature for methods involving guidance or monitoring of HIFU by use of photoacoustics. The prototype is first characterized in terms of both photoacoustic and HIFU performances. The probe is then used to perform an idealized scenario of photoacoustic-guided therapy, where photoacoustic signals generated by an absorbing thread embedded in a piece of chicken breast are used to automatically refocus a HIFU beam with a time-reversal mirror and necrose the tissue at the location of the absorber.

Paper Details

Date Published: 7 May 2012
PDF: 7 pages
J. Biomed. Opt. 17(6) 061205 doi: 10.1117/1.JBO.17.6.061205
Published in: Journal of Biomedical Optics Volume 17, Issue 6
Show Author Affiliations
Amaury Prost, Ecole Supérieure de Physique et de Chimie Industrielles (France)
Arik R. Funke, Ecole Supérieure de Physique et de Chimie Industrielles (France)
Mickael Tanter, Ecole Supérieure de Physique et de Chimie Industrielles (France)
Jean-François Aubry, Ecole Supérieure de Physique et de Chimie Industrielles (France)
Emmanuel Bossy, Ecole Supérieure de Physique et de Chimie Industrielles (France)


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