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Journal of Biomedical Optics • Open Access

In-situ imaging of articular cartilage of the first carpometacarpal joint using co-registered optical coherence tomography and computed tomography
Author(s): Paul Cernohorsky; Simon D. Strackee; Daniel M. de Bruin; Marcel B. van Herk; Dirk J. Faber; Ton G. van Leeuwen; Johannes Bras

Paper Abstract

Conventional imaging modalities are unable to depict the early degeneration of articular cartilage in osteoarthritis, especially in small joints. Optical coherence tomography has previously been used successfully in high-resolution imaging of cartilage tissue. This pilot cadaver study demonstrates the use of intra-articular optical coherence tomography in imaging of articular cartilage of the first carpometacarpal joint, producing high resolution images of the articular surface in which cartilage thickness and surface characteristics were assessed. Findings on optical coherence tomography were confirmed with histology. Furthermore, co-registration of optical coherence tomography and computed tomography was used to accurately determine the scanned trajectory and reconstruct a true-scale image overlay.

Paper Details

Date Published: 16 May 2012
PDF: 4 pages
J. Biomed. Opt. 17(6) 060501 doi: 10.1117/1.JBO.17.6.060501
Published in: Journal of Biomedical Optics Volume 17, Issue 6
Show Author Affiliations
Paul Cernohorsky, Academisch Medisch Ctr. (Netherlands)
Simon D. Strackee, Academisch Medisch Ctr. (Netherlands)
Daniel M. de Bruin, Academisch Medisch Ctr. (Netherlands)
Marcel B. van Herk, Netherlands Cancer Institute (Netherlands)
Dirk J. Faber, Academisch Medisch Ctr. (Netherlands)
Ton G. van Leeuwen, Academisch Medisch Ctr. (Netherlands)
Johannes Bras, Academisch Medisch Ctr. (Netherlands)

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